Can Out of Stem Cells Regenerate Normal cartilage?

Lay media pay attention to stem cell (SC) therapy has generally dedicated to two areas:

1. The declaration of embryonic SC
2. The proliferation of charlatans preying nonetheless the dreams and fears a good helpless patients.

While embryonic SC, in theory, appear to potentially be the better option for tissue regrowth, the hype has exceeded the hope. Because of political extremely ethical concerns, research efforts with your cells has been deflating.

At the same free time, news articles and television commentaries also have dealt with controversial areas of SC therapy. An inordinate timeframe has been devoted to exposing the seamy attribute... individuals involved in drab hucksterism, the possible infringe of SC therapy by practitioners, as well the moment the implication that all SOUTH CAROLINA research conducted outside helpful centers is suspect.

As a consequence, there has been neglect regarding on the fascinating and promising businesses, particularly in arthritis treatment methods.

One of the so very much more intriguing studies was recently authored by Korean investigators (Pak N. Regeneration of human steak in hip osteonecrosis whilst in the human cartilage in lower - leg osteoarthritis with autologous adipose-derived come cells: a case sequence. J Med Case Research. 2011; 7: 296)

The Japanese physicians treated four matters. Two (a 29 year old woman and a 47 yr old man) had osteonecrosis of that hip. Two other patients (a 70 year old woman and a 79 yr old man) had osteoarthritis of that knee. They were all given a mixture of autologous stem cells (the dental patient's own stem cells) via fat along with platelet it had been plasma, hyaluronic acid, nanogram levels of dexamethasone, and calcium chloride.

Pre and post specialists MRI scans were located in all subjects. In the disease of patients with osteonecrosis, new bone formation was cited. In the patients into it osteoarthritis, new cartilage composition was seen.

Along right to MRI findings, both subjective pain measures and these outcomes improved.

I found these findings in order to be extremely interesting only a few reasons.

First, the mixture used scenario Korean report resembles the one that might use at our location, with one exception. The exception has it been: In addition to the SC, we also simply bone marrow derived set up cells.

And, while our center has already established excellent results with leg osteoarthritis (more than 90 per cent success), our experience with both hip osteoarthritis and this will hip osteonecrosis has ended up disappointing.

Why the difference between hip and knee? I suspect it's because the mechanical forces are very different. The anatomy of used up hip joint allows extreme rotation instead of the knee joint which is especially a hinge joint a few rotation and some gliding. Activity level and body weight are often contributing factors.

Nonetheless, this report from Korea underscores what we believe really was... the use of autologous set up cells, also known in something repair stem cells, will developed into a fruitful area along with progress in osteoarthritis research for years into the future.

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